The microbiome has become one of the most exciting areas for research and translational science in the biopharmaceutical industry.
This company has a class-leading platform which enables precise and large-scale identification of gut bacteria associated with health or disease, enabling the design of novel medicines and biomarkers based on live bacteria. In a short space of time, the company has established itself as an industry leader to discover novel biomarkers, targets and medicines in inflammatory bowel disease. They have a pipeline of live bacterial products for C. difficile, ulcerative colitis and cancer which will be progressed to the clinic.
This is an exciting opportunity for an enthusiastic scientist to play a key role in building a new biotech company, take a leadership position in the exciting new field of microbiome-host interaction research and to contribute to the development of a new class of medicines.
Role and Responsibilities
We are now seeking an experienced and highly motivated cell biologist with an interest in translational research and the development of novel live bacterial therapies for future clinical trials. The ideal candidate is an enthusiastic cell biologist with extensive immunology and a strong interest in mucosal immunology and its modulation by the gut microbiota. Besides a proven strong commitment to immunology disease research, extensive expertise in tissue culture, flow cytometry and cellular immunology techniques is essential. A background in immuno-oncology would be an advantage. We are looking for self-driven and dynamic candidates that thrive on leading and being part of a team and can efficiently work as individuals with excellent communication and project management skills and a proven track record of teamwork, adaptability, innovation, initiative and integrity.
The successful candidate will play a key role in the discovery of novel therapeutic candidates comprising a consortium of live bacteria delivered orally to the intestinal tract, initially in our ulcerative colitis and immuno-oncology programs.
The successful candidate will be responsible for the development and performance of relevant cellular immunology assays and flow cytometry to allow the selection and functional characterisation of candidate bacteria.
The major areas of responsibility are:
- Set up and develop mammalian cell biology and organoid capability for testing of modulation by anaerobic gut bacteria.
- Develop immunological assays and gut cellular models for functional characterization of candidate bacteria.
- Liaise with external CROs to develop assays to support projects where necessary.
- Maintain a strong knowledge of, and developments in, immunology and microbiome biology.
- Ensure integrity of data from the group within the program teams.
- Be an effective and accountable contributor within program teams.
- Manage, mentor and develop group members.
Requirements for this post include:
- PhD in mucosal immunology or a related field with a strong translational focus.
- Experience of autoimmune disease or cancer immunology, ideally in an industry setting.
- Demonstrable ability to exercise scientific judgement in defining and progressing projects suitable for drug development.
- Proven management experience.
- Excellent interpersonal communication skills.
- Demonstrable and outstanding personal initiative, ability to work effectively as part of a team, meet deadlines and efficiently multitask.
- Demonstrable ability to work on problems of diverse scope in which analysis of data requires evaluation of creative input.
- Strong leadership skills.